The impact of perinatal low-calorie sweetener exposure on the development of neural systems involved in metabolic regulation JCI_insight USC maxplanckpress unccharlotte sweetener diet health metabolism maternalhealth
By Dr. Sanchari Sinha Dutta, Ph.D.Apr 6 2023Reviewed by Danielle Ellis, B.Sc. The study identifies a gut microbial-host co-metabolite as a potential causative factor mediating these changes.
Besides affecting adult metabolism, exposure to low-calorie sweeteners during pregnancy is known to cause adversities in infants, including body weight gain, insulin resistance, development of sweet taste preference, and alteration of gut microbiota composition. Study design The study was conducted on adult female mice exposed to two commonly used low-calorie sweeteners, namely aspartame and rebaudioside A, during pregnancy and lactation periods.Important observations The exposure to low-calorie sweeteners during pregnancy and lactation induced certain changes in adult female mice. The mice exposed to rebaudioside A showed a redistribution of body composition, including a reduction in fat mass and an induction in lean mass.
The male offspring exhibited increased fat mass, reduced lean mass, and glucose intolerance compared to non-exposed control offspring. The study conducted an untargeted metabolomic analysis of maternal milk and offspring blood samples. In both samples, considerable changes in metabolite profiles due to low-calorie sweetener exposure were observed.
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