Dr. Tilman explains the functions of iPSC-derived microglia and their relevance to conditions like Alzheimer’s.
Sponsored Content by Axol Bioscience LtdSep 17 2024 insights from industryDr. Jessica TilmanScientific Group LeaderAxol Bioscience In this interview, Dr. Tilman explains the functions of iPSC-derived microglia and their relevance to conditions like Alzheimer’s and other neurodegenerative diseases.
Activated microglia release pro-inflammatory mediators and are thought to aid in the growth of protein aggregates, which causes additional degeneration. Dysfunctional microglia can cause excessive inflammation, synapse loss, and a failure to update accumulated proteins and toxic cell debris. What assays can you run using microglia? Microglia can be used in a variety of applications, including monoculture chemical screening and co-culture with neurons and astrocytes. We have various optimized assays that have been extensively used, and we are always willing to design new assays on request.How does Axol ensure quality control for iPSC-derived microglia cells? The first step is to ensure that all iPSCs are of high quality and have passed our internal quality control checks.
How easy is it to use axoCellsTM microglia ourselves? axoCells iPSC-derived microglia are straightforward to culture and assay-ready within seven days after thawing. User manuals are provided, and all necessary media can be sourced from Axol to ensure consistency with the in-house data. Technical support is always available for any issues or specific questions.
Microglia Research Alzheimer's Disease Brain Cell Cytometry Embryonic Development Flow Cytometry Immune System Inflammation Neurons Pathology Ph Phagocytosis Pluripotency Progenitor Cells Protein QC Quality Control
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