In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team has now discovered that a factor secreted by tumor cells is responsible for the resistance. These findings could pave the way for more effective therapies.
In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance. These findings could pave the way for more effective therapies.
"It is therefore crucial to understand the mechanism behind resistance development in melanoma," says Lukas Sommer, professor of stem cell biology at the Institute of Anatomy at the University of Zurich . A study under his lead has now identified a mechanism that impedes the effectiveness of therapies. The result provides new ideas for treatments to suppress the development of resistance.
Through a series of further experiments -- both with human cancer cells and with mice -- the research team was able to show how the interaction of increased POSTN levels and this type of macrophage triggers resistance: the POSTN factor binds to receptors on the surface of the macrophages and polarizes them to protect melanoma cells from cell death."This is why the targeted therapy no longer works," says Sommer.The team considers this mechanism a promising starting point.
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