The nature of the immune responses induced by various COVID-19 vaccines developed using different platforms and formulations MercerYou ASU Penn immune covid coronavirus COVID19 vaccine vaccination
By Bhavana KunkalikarFeb 7 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in the Journal of Pharmaceutical Sciences, researchers reviewed existing achievements and shortcomings in severe acute respiratory syndrome coronavirus 2 vaccine platforms, as well as future-generation vaccine considerations.
The urgent demand for a SARS-CoV-2 vaccine was met swiftly, effectively curbing the pandemic. However, with emerging reports of waning vaccine effectiveness and adverse effects, novel platforms need investigation. Considerations for novel vaccine delivery systems Investigations are still needed to understand the precise characteristics of the protective immunological response against COVID-19. The induction of cellular and humoral immune responses is based on the processing and manifestation of protein antigens by major histocompatibility complex class I and class II molecules, which further stimulate CD4 and CD8 positive T cells.
Protection against COVID-19 involves numerous immunological components. While vaccines effectively induce effector mechanisms, including cytotoxic T lymphocytes and neutralizing antibodies, other pathways like antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, induction of broadly neutralizing antibodies, the kinetics involved in cytokines and their receptors, and stimulation of non-T cell responses remain poorly understood.
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