It's time to wrap up warm aff 🥶
The cost of living is an ongoing crisis which is seeing millions of people up and down the UK cut back on costs.
READ MORE: DWP Cost of Living payment changes for 2023 including Universal Credit and energy discounts And yes, that even includes your dog with Oodie making several small versions for your furry friend. They even sell an Adult & Dog Oodie Bundle - we now, its too cute.
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I’m a foodie and make a whole Sunday roast beef in my Air Fryer - here's howA FOODIE has shared how you can make a whole roast beef just using your Air Fryer. Air Fryers soon shot up in popularity and became one of the must-have home kitchen gadgets of 2022. Fans of …
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Food inflation 'hit record high' ahead of Christmas led by fresh produceThe cost of food continues to mount but a retail body says inflation across the sector as a whole is being held back by discounting in a bid to shift stock.
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Food inflation 'hit record high' ahead of Christmas led by fresh produce as spend £1bn higher than 2021The cost of food continues to mount, as £12.8bn spent, but a retail body says inflation across the sector as a whole is being held back by discounting in a bid to shift stock.
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Genome-Wide Pleiotropy Study Identifies Association of PDGFB with Age-Related Macular Degeneration and COVID-19 Infection OutcomesAge-related macular degeneration (AMD) has been implicated as a risk factor for severe consequences from COVID-19. We evaluated the genetic architecture shared between AMD and COVID-19 (critical illness, hospitalization, and infections) using analyses of genetic correlations and pleiotropy (i.e., cross-phenotype meta-analysis) of AMD (n=33,976) and COVID-19 (n ≥ 1,388,342) and subsequent analyses including expression quantitative trait locus (eQTL), differential gene expression, and Mendelian randomization (MR). We observed a significant genetic correlation between AMD and COVID-19 infection (rG=0.10, p=0.02) and identified novel genome-wide significant associations near PDGFB (best SNP: rs130651; p=2.4 × 10−8) in the pleiotropy analysis of the two diseases. The disease-risk allele of rs130651 was significantly associated with increased gene expression levels of PDGFB in multiple tissues (best eQTL p=1.8 × 10−11 in whole blood) and immune cells (best eQTL p=7.1 × 10−20 in T-cells). PDGFB expression was observed to be higher in AMD cases than AMD controls {fold change (FC)=1.02; p=0.067}, as well as in the peak COVID-19 symptom stage (11–20 days after the symptom onset) compared to early/progressive stage (0–10 days) among COVID-19 patients over age 40 (FC=2.17; p=0.03) and age 50 (FC=2.15; p=0.04). Our MR analysis found that the liability of AMD risk derived from complement system dysfunction {OR (95% CI); hospitalization=1.02 (1.01–1.03), infection=1.02 (1.01–1.03) and increased levels of serum cytokine PDGF-BB {β (95% CI); critical illness=0.07 (0.02–0.11)} are significantly associated with COVID-19 outcomes. Our study demonstrated that the liability of AMD is associated with an increased risk of COVID-19, and PDGFB may be responsible for the severe COVID-19 outcomes among AMD patients.
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