Findings indicate HR-HPV infections affect sperm health, increasing oxidative stress and altering cytokine levels, emphasizing HPV's impact on male fertility.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMAug 27 2024 In a recent study published in the Frontiers of Cellular and Infection Microbiology , a group of researchers investigated the association of high-risk and low-risk human papillomavirus infections with sperm quality, oxidative stress , and inflammation in the male urogenital tract.
While HPV in men has been less studied, recent research highlights its prevalence and potential effects on male reproductive health. HPV Deoxyribonucleic Acid has been detected in various male genital specimens, but its impact on sperm quality and semen inflammation remains unclear. Exclusion criteria included prior HPV vaccination, vasectomy , azoospermia , significant varicocele , exposure to environmental pollutants, alcohol, drug, or marijuana use, recent fever, or antibiotic treatment.
Semen quality was assessed according to World Health Organization guidelines, and sperm apoptosis/necrosis, cytokine levels, leukocyte subsets, and reactive oxygen species production were measured using flow cytometry and Enzyme-Linked Immunosorbent Assay . Statistical analyses were conducted using GraphPad Prism and SPSS, with significance set at p < 0.05.
To assess the potential impact of HR-HPV and LR-HPV on male fertility, the study analyzed sperm quality and apoptosis/necrosis in infected patients compared to controls. Routine sperm parameters showed no significant differences between controls and those infected with either HR-HPV or LR-HPV. The study further examined the role of co-infections with other uropathogens in HR-HPV-positive patients. While co-infections did not significantly alter conventional sperm quality parameters, they did exacerbate sperm necrosis and ROS production. Despite these effects, semen inflammation remained minimal, with reduced levels of Cluster of Differentiation 45+ leukocytes observed in co-infected individuals.
Oxidative Stress Sperm Stress Apoptosis Cancer Cervical Cancer Cytokines DNA Genotyping Inflammation Leukocyte Microbiology Necrosis Oxygen Reproductive Health Research Semen Urology Virus
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