Scientists have discovered that the most widely-used class of antifungals in the world cause pathogens to self-destruct. The research could help improve ways to protect food security and human lives.
Scientists have discovered that the most widely-used class of antifungals in the world cause pathogens to self-destruct. The University of Exeter-led research could help improve ways to protect food security and human lives.
Our strongest"weapon" against fungal plant diseases are azole fungicides. These chemical products account for to a quarter of the world agricultural fungicide market, worth more than £3 billion per year. Antifungal azoles are also widely used as a treatment against pathogenic fungi which can be fatal to humans, which adds to their importance in our attempt to control fungal disease.
, University of Exeter scientists have uncovered the cellular mechanism by which azoles kill pathogenic fungi. Lead author Professor Gero Steinberg, who holds a Chair in Cell Biology and is Director of the Bioimaging Centre at the University of Exeter, said:"Our findings rewrite common understanding of how azoles kill fungal pathogens. We show that azoles trigger cellular"suicide" programmes, which result in the pathogen self-destructing.
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