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biohybrid microrobotsare typically made of rigid metallic or polymeric structures that are difficult to manufacture. They're unable to access certain organs and tissues, and they can be toxic to humans., with nanoparticles coated with red blood cell membranes.
We tested our algae-based microrobots in mice with lung metastases. By administering these algae-based microrobots through the trachea, we could transport the drug directly into the lungs and minimize side effects to other organs. Compared with free drug and static drug-loaded nanoparticles that cannot move on their own, our biohybrid microrobots accumulated in greater concentrations and were retained longer in the lungs.
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