Patients with late-stage cancer often have to endure multiple rounds of different types of treatment, which can cause unwanted side effects and may not always help.
Massachusetts Institute of Technology Oct 29 2024
One of the examples where this particular technology could be useful is trying to control the growth of really fast-growing tumors. The goal would be to gain some control over these tumors for patients that don't really have a lot of options, and this could either prolong their life or at least allow them to have a better quality of life during this period.
The MIT team wanted to come up with a way to deliver phototherapy and chemotherapy together, which they thought could make the treatment process easier on the patient and might also have synergistic effects. They decided to use an inorganic material called molybdenum sulfide as the phototherapeutic agent. This material converts laser light to heat very efficiently, which means that low-powered lasers can be used.
"The advantage of this platform is that it can act on demand in a pulsatile manner," Kanelli says. "You administer it once through an intratumoral injection, and then using an external laser source you can activate the platform, release the drug, and at the same time achieve thermal ablation of the tumor cells."
"This machine-learning-optimized laser system really allows us to deploy low-dose, localized chemotherapy by leveraging the deep tissue penetration of near-infrared light for pulsatile, on-demand photothermal therapy. This synergistic effect results in low systemic toxicity compared to conventional chemotherapy regimens," says Neelkanth Bardhan, a Break Through Cancer research scientist in the Belcher Lab, and second author of the paper.
Microparticles Breast Cancer Chemotherapy Doxorubicin Drugs Heat Machine Learning Phototherapy Research Technology Tumor
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