Tirzepatide shows promise in reducing weight and preventing diabetes progression in people with obesity and prediabetes, with lasting benefits and manageable side effects.
By Dr. Sushama R. Chaphalkar, PhD.Reviewed by Susha Cheriyedath, M.Sc.Nov 14 2024 A long-term study reveals how tirzepatide not only cuts weight but also slashes diabetes risk in people with prediabetes, highlighting a major advance in obesity and diabetes care.
Obesity, affecting nearly a billion people worldwide, is closely linked to prediabetes, which raises the lifetime risk of developing T2D by up to 70%. Obesity, a chronic neuroendocrine disease, exacerbates insulin resistance and pancreatic beta-cell dysfunction, fueling diabetes progression. In the SURMOUNT-1 trial, a 15-mg dose helped participants lose over 20% of body weight in 72 weeks with marked reductions in glycated hemoglobin . In the present article, researchers reported the three-year safety and efficacy outcomes of tirzepatide in participants with obesity and baseline prediabetes.
The primary outcome in the analysis was the percent change in body weight and prevention of diabetes onset by week 176, with follow-up through week 193. Glycemic status, blood pressure, lipid levels, and quality of life were regularly assessed. Tirzepatide also significantly reduced the onset of T2D, with only 1.3% of participants in the treatment groups developing T2D compared to 13.3% in the placebo group .
Obesity Prediabetes Agonist Blood Blood Pressure Blood Sugar Cardiometabolic Chronic Efficacy GLP-1 Glucose Hyperglycemia Insulin Insulin Resistance Medicine Placebo Receptor Type 2 Diabetes Weight Loss
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