Actinium-targeted alpha radiotherapy is a promising approach for treating metastatic cancers, including prostate cancer. This approach requires doctors to obtain images of the radiotherapy agent as it moves to tumors, a process called molecular imaging. Attaching a radioisotope to a chemical compound is called radiolabeling. Conducting a molecular imaging study with a radiolabeled compound allows doctors to plan treatments.
However, this imaging step is not possible with therapeutic substances labeled with actinium-225 . A desired imaging isotope must be similar to Ac-225's half-life and chemistry and also provide a decay emission that allows for imaging; few such isotopes exist. Researchers have proposed using cerium/lanthanum-134 as an imaging material for Ac-225. This study examined the performance of cerium-134 as an imaging surrogate in combination with Ac-225.
To make cancer treatments successful, doctors must perform imaging to help guide their therapy decisions. Ac-225 therapy demonstrates great promise for prostate and other cancers. To make this radioisotope more useful, this research developed a single molecular platform for imaging and radiotherapy using Ac-225 and Ce-134. The results demonstrate similar tumor uptake for Ce-134 and Ac-225 inmodels.
Theranostics is an emerging field combining imaging and therapy, allowing a personalized approach to treating cancer and other diseases. The use of theranostics in
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