Transplacental passage of specific IgG in maternal SARS-CoV-2 infection infection pregnancy COVID19 coronavirus covid SARSCoV2 antibody maternal disease
By Tarun Sai LomteSep 13 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in the Journal of Medical Virology, researchers analyzed antibody profiles of mothers infected with severe acute respiratory syndrome coronavirus 2 and their offspring.
At delivery, all SARS-CoV-2-positive women and their neonates were screened for anti-spike IgM and IgG antibodies. SARS-CoV-2 PCR tests were also performed on newborns a day after birth. Electronic medical records were accessed to obtain information on age, delivery type, COVID-19 symptoms and severity, the time between positive test and delivery, neonatal PCR data, and maternal and neonatal serologic status.
In group 1, three mothers and two neonates were positive for anti-spike IgG antibodies. In the second group, 27 females and 22 newborns exhibited IgG positivity. Fourteen women and eight neonates from group 3 had IgG antibodies. Nineteen women and 16 newborns from group 4 developed IgG antibodies. There were five IgG-positive neonates born to IgG-negative mothers.