A common infection-causing bacteria was much less likely to evolve antibiotic resistance when treated with a mixture of antimicrobial peptides rather than a single peptide, making these mixtures a viable strategy for developing new antibiotic treatments.
Jens Rolff of the Freie Universitat Berlin, Germany, and colleagues report these findings in a new study publishing July 2 in the open-access journalAntibiotic-resistant bacteria have become a major threat to public health. The World Health Organization estimates that 1.27 million people died directly from drug-resistant strains in 2019 and these strains contributed to 4.95 million deaths.
Overall, the findings suggest that the use of antimicrobial peptide mixtures is a strategy worth pursuing in the search for new, longer-lasting treatments for bacteria. The researchers suspect that using a cocktail of multiple antimicrobial peptides creates a larger set of challenges for bacteria to overcome, which can potentially delay the evolution of resistance, compared to traditional antibiotics.
Bernardo Antunes, Caroline Zanchi, Paul R. Johnston, Bar Maron, Christopher Witzany, Roland R. Regoes, Zvi Hayouka, Jens Rolff.A new powerful antibiotic, isolated from bacteria that could not be studied before, seems capable of combating harmful bacteria and even multi-resistant 'superbugs'. Named Clovibactin, the antibiotic ...
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