A study of horses – which share many important similarities with humans in their chromosomes and pregnancies – revealed that 42% of miscarriages and spontaneous abortions in the first two months of pregnancy were due to complications from an extra set of chromosomes, a condition called triploidy.
Cornell UniversityAug 5 2024
"We were able to study the impact of chromosome errors across the entire pregnancy in the horse," de Mestre said. "We found that triploidy is only associated with losses in early pregnancy." Reasons for miscarriage in women in very early pregnancy have been difficult to determine because most fetuses during this period are lost at home, leaving scientists without material – and data – to study. The study's findings provide insight into the frequency of chromosome errors over the equivalent period of the first six weeks of human gestation.
In terms of equine health, the study provides new details about common chromosomal abnormalities that will likely change the clinical management of pregnancies. For example, if a clinician determines that a horse has a major chromosomal error, they may no longer choose to extend that pregnancy by administering hormones, a common practice in pregnant mares.
Pregnancy Chromosome Conception Genetic Medicine Miscarriage Research Triploidy Veterinary
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