Significant progress has been made at Tufts University School of Engineering in the development of a small device, about the size of a vitamin pill, that can be swallowed and passed through the gastrointestinal tract to sample the full inventory of microorganisms in an individual's gastro-intestinal tract.
Tufts UniversityJun 14 2024 Significant progress has been made at Tufts University School of Engineering in the development of a small device, about the size of a vitamin pill, that can be swallowed and passed through the gastrointestinal tract to sample the full inventory of microorganisms in an individual's gastro-intestinal tract. This device has the potential to advance research on the relationship between resident bacteria and a wide range of health conditions.
The device has completed preclinical characterization – as presented in the journal Device - paving the way for upcoming human clinical trials. It is characterized by a 3D printed soft elastic exterior with sidewall inlets that open in response to the changing acidity as the pill reaches the small intestine. The pill uses elastic microvalves with swellable polyacrylate beads that close the inlets once intestinal content has been collected.
Improvements over previous versions of the pill include using a soft elastic exterior rather than a rigid shell, to make it easier to ingest, and significantly improved control over localized sampling of the microbiome in the small intestine. Current techniques to study the intestinal microbiome primarily rely on fecal matter , This technology represents a significant advance in understanding the function of the thousands of microbial species populating the entire length of the gastrointestinal tract and their effects on health.
Technology Gastrointestinal Tract Preclinical Research Small Intestine
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