Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease (NAFLD), impacts roughly 30% of the global adult population.
INSERM Dec 9 2024 Metabolic dysfunction-associated steatotic liver disease , formerly referred to as nonalcoholic fatty liver disease , impacts roughly 30% of the global adult population. The disease spans from benign fat accumulation in the liver to its more severe form, metabolic dysfunction-associated steatohepatitis . MASH represents a dangerous progression, with the potential to cause cirrhosis, liver cancer , type 2 diabetes , and cardiovascular disease .
Two subtypes of MASH, two distinct risk profiles The study identified and validated two distinct types of MASH based on histology and liver imaging, using data from European cohorts and the UK Biobank: "This research marks a turning point," says Prof. François Pattou. "We now have a clear path to develop subtype-specific treatments that can improve patient outcomes."
The science behind the subtypes The study utilized data from the French ABOS cohort of 1,389 individuals with obesity and validated its findings across three European MASLD cohorts , comprising 1,099 participants, as well as imaging data from over 6,000 UK Biobank participants. By integrating clinical traits with liver transcriptomics and plasma metabolomics, researchers uncovered distinct biological pathways driving each subtype.
Liver Liver Disease Cancer Cardiometabolic Cardiovascular Disease Cirrhosis Diabetes Diagnostic Hospital Imaging Liver Cancer Medicine Research Steatosis Type 2 Diabetes UK Biobank
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