Researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital and collaborating institutions discovered that the enzyme TYK2 transforms the normal protein tau into one that accumulates in the brain and contributes to the development of Alzheimer's disease in animal...
Baylor College of Medicine Nov 12 2024 Research ers at Baylor College of Medicine , the Jan and Dan Duncan Neurological Research Institute at Texas Children 's Hospital and collaborating institutions discovered that the enzyme TYK2 transforms the normal protein tau into one that accumulates in the brain and contributes to the development of Alzheimer's disease in animal models.
Previous studies showed that tau is chemically modified in disease, predominantly by the addition of extra phosphate to the Tyrosine groups in the protein, and that these changes play a crucial role in regulating tau accumulation. Working with human cells and animal models of tau-driven dementia, the researchers are the first to show that TYK2's modifications to tau contribute to tau-mediated disease. "We found that TYK2 adds phosphate groups to tau at a particular location on the protein identified as Tyrosine 29," Kim said. "This modification stabilizes tau levels in human cells and mouse neurons by making it resistant to autophagy, a cellular process important for clearing proteins," Kim said.
Brain Children Enzyme Genetics Hospital Medicine Neurons Neuroscience Protein Research Tyrosine
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Researchers uncover distinct cell vulnerabilities in Alzheimer’s progression with novel multiomics approachResearchers used single-cell and spatial genomics to map cell-type-specific changes in the middle temporal gyrus, identifying distinct disease phases in Alzheimer’s progression.
Read more »
Duncan Ferguson picks up petrol bill for crestfallen Inverness starsFerguson has been going above and beyond to look after his players as administration looms
Read more »
Leon Marchand beats Duncan Scott at World Cup event in ShanghaiFrance's Leon Marchand beats Great Britain's Duncan Scott to win the men's 200m individual medley at the short course World Cup event in Shanghai.
Read more »
Duncan Ferguson does not expect to remain Inverness CT bossDuncan Ferguson does not expect to remain Inverness CT boss
Read more »
Duncan Scott wins 200m freestyle at World Cup event in ShanghaiGreat Britain's Duncan Scott claims victory in the men's 200m freestyle on the third and final day of the short course World Cup event in Shanghai.
Read more »
Duncan Ferguson axed as Inverness boss as administrators start Caley clearoutThe crisis hit club have started the cost cutting process in the Highlands
Read more »