Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have received an $800,000 grant from the V Foundation to find new ways to treat and prevent a severe form of kidney cancer associated with a hereditary syndrome caused by mutations in the fumarate hydratase (FH) gene.
University of California - Los Angeles Health SciencesJul 16 2024 Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have received an $800,000 grant from the V Foundation to find new ways to treat and prevent a severe form of kidney cancer associated with a hereditary syndrome caused by mutations in the fumarate hydratase gene.
Patients with HLRCC face a high risk of developing kidney cancer at a young age and uterine fibroids often lead to hysterectomy in young women impairing their fertility. Our goal is to identify treatments that can either prevent the onset of cancer and the benign manifestations or manage its progression more effectively."
The team plan to open a clinical trial investigating the use of 6-mercaptopurine , a medication commonly used to treat inflammatory disorders or hematologic cancers, in patients with HLRCC. Preliminary studies in mice have shown promising results, with 6MP effectively blocking tumor growth by targeting the tumor's reliance on purine salvage, a key metabolic process.
Kidney Kidney Cancer Clinical Trial Gene Genetic Purine Research Syndrome Tumor Uterine Fibroids
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