UCLA scientists have identified the protein GPNMB as a critical regulator in the heart's healing process after a heart attack.
University of California - Los Angeles Health SciencesOct 25 2024 Findings UCLA scientists have identified the protein GPNMB as a critical regulator in the heart's healing process after a heart attack .
Background Every 40 seconds, someone in the United States has a heart attack -; the leading cause of heart failure. These cardiac events weaken the heart and cause scarring that reduces the heart's ability to pump blood effectively. And while this scar tissue forms initially to maintain the heart's structure, it remains permanently, straining the surviving muscle and eventually leading to heart failure.
Method Utilizing mouse models, the researchers first established that GPNMB is not natively expressed by the heart itself but is produced by inflammatory cells originating from the bone marrow. After a heart attack, these macrophages travel to the site of injury in the heart, where they express GPNMB.
Related StoriesIn addition to identifying GPNMB as a signaling molecule with effects across various cell types, the researchers uncovered that it binds to GPR39, previously considered an orphan receptor, or a receptor whose binding partner is not known. This interaction triggers a cascade of signals that promote tissue regeneration and limit scarring.
Protein Blood Bone Bone Marrow Cell Gene Heart Attack Heart Failure Medicine Muscle Receptor Research Scar
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