University of Florida Health scientists exploring how combinations of antibiotics can fight resistant bacteria have been awarded an $11.8 million grant for work that could help save the tens of thousands of lives lost yearly to infections that are increasingly plaguing humanity.
University of FloridaOct 17 2024 University of Florida Health scientists exploring how combinations of antibiotics can fight resistant bacteria have been awarded an $11.8 million grant for work that could help save the tens of thousands of lives lost yearly to infections that are increasingly plaguing humanity.
Accordingly, the National Institute of Allergy and Infectious Diseases, under the NIH, solicited competitive proposals in a "call to arms" to address the crisis, UF Health researchers said. The hope is to "dial in" these antibiotics using newfound insight from the laboratory. It's like understanding an enemy's weaknesses to form a battle plan that takes advantage of those chinks in the armor.
"These bacteria are not only multi-resistant to antibiotics, they're also hypervirulent," said Drusano. "They have turned into really nasty, nasty bugs that wreak havoc on patients' bodies and too often kill them. We have some great antibiotics. But we need to optimize them and find new approaches that will cure people and get them out of the hospital."
These bacteria reproduce and evolve in rapid cycles of life and death as short as 20 to 30 minutes, and generations of reproduction are achieved in days. A severe infection might generate billions of bacteria in the lungs, making it highly probable that a beneficial bacterial adaptation will get a toehold, defanging an antibiotic.
Bacteria Acinetobacter Acinetobacter Baumannii Allergy Children Drugs Genetic Hair Hospital In Vitro Infectious Diseases Laboratory Lungs Medicine Ph Pharmacy Reproduction Research
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