The National Institutes of Health recently awarded $2.
University of Massachusetts AmherstOct 7 2024 2 million to Alissa Rothchild, assistant professor in the Department of Veterinary and Animal Sciences at the University of Massachusetts Amherst and an expert in tuberculosis immunology, to study the very first cells that respond to Mycobacterium tuberculosis , the bacteria causing TB.
While the adaptive immune system is very effective, it is not the body's first responder -; that is the job of the innate immune system and its ranks of macrophages. Macrophages are the firstline defenders in the tissues that recognize and destroy pathogens and also call for backup. One way they do this is by turning on different inflammatory programs that can change the tissue environment.
To figure out how to more precisely target the AMs, Rothchild has three aims for her NIH-supported research. First, to understand how AMs sense Mtb. Second, to understand what role interferons, specialized proteins that help host cells respond to pathogens, play in changing the AM response to Mtb. And third, to determine how altering AM responses might affect the host's response to Mtb infection without disrupting the important homeostatic balance in the lung.
Bacteria Cell Immune Response Immune System Immunity Immunology Lungs Veterinary
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