Fewer side effects, improved chances of healing: the goal of precision medicine is to provide patients with the most individualized treatment possible. This requires a precise understanding of what is happening at the cellular level.
Technical University of Munich Aug 2 2024 Fewer side effects, and improved chances of healing: the goal of precision medicine is to provide patients with the most individualized treatment possible. This requires a precise understanding of what is happening at the cellular level. For the first time, researchers at the Technical University of Munich have now succeeded in mapping the interactions of 144 active substances with around 8,000 proteins.
Large numbers of results in a short time To do this, the researchers treated cells with various doses of 144 active substances over an 18-hour period. Most of the drugs are already being used in cancer treatment or are in the clinical approval stage. After being extracted, the proteins were analyzed with mass spectrometry. The team then used the data to study the cell reactions.
Recognizing the potential of existing drugs Cancer is a prime example of why a detailed understanding of these processes is so important: Depending on the type of cancer, very different things are happening at the molecular level. This is decisive for selecting suitable treatments and may offer clues for the development of new drugs. With the data the team was able to show, for example, that the immune system can be weakened by a class of drugs known as HDAC inhibitors.
Medicine Precision Medicine Biotechnology Cancer Cell Immune System Proteomics Research Spectrometer
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