Pancreatic ductal adenocarcinoma (PDAC) is recognized as one of the most lethal cancers, with an estimated five-year survival rate of approximately 10%.
Xia & He Publishing Inc.Nov 7 2024 Pancreatic ductal adenocarcinoma is recognized as one of the most lethal cancers, with an estimated five-year survival rate of approximately 10%. This poor prognosis is largely attributed to the challenges in early diagnosis, aggressive tumor biology, and limited treatment options.
Gut dysbiosis in PDAC Research highlights significant alterations in the gut microbiota composition of PDAC patients compared to healthy individuals. For instance, studies using stool samples have identified a higher abundance of Streptococcus and Veillonella species in PDAC patients, along with a notable decrease in beneficial strains such as Faecalibacterium prausnitzii.
Microbiota-derived metabolites and PDAC Gut microbiota produces a variety of metabolites that affect the host's physiological processes, including inflammation, immune responses, and even tumor cell behavior. Short-chain fatty acids , such as butyrate, are among the most researched microbial metabolites and have been shown to suppress PDAC cell invasiveness in laboratory settings.
Dysbiosis Fecal Microbiota Transplantation Pancreatic Cancer Adenocarcinoma Bacteria Cell Efficacy Fatty Acids Immune Response Immunotherapy Metabolism Metabolites Microbiome Research Short-Chain Fatty Acids Tumor
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