β-Thalassemia is a genetic disorder characterized by reduced or absent synthesis of the beta chains of hemoglobin, leading to ineffective erythropoiesis and severe anemia.
Xia & He Publishing Inc.Jul 29 2024 Patients with transfusion-dependent β-thalassemia require regular blood transfusions to maintain adequate hemoglobin levels. Non-transfusion-dependent thalassemia patients manage their anemia without regular transfusions but still experience significant health complications. Iron overload is a common and severe complication in both TDT and NTDT patients due to increased intestinal iron absorption and regular transfusions.
Diagnosis and monitoring Diagnosing iron overload involves several parameters, with serum ferritin levels being a primary indicator. Elevated serum ferritin levels, typically above 300 ng/ml in males and 150–200 ng/ml in females, signal excess iron accumulation. However, inflammation, infection, and liver disorders can affect ferritin levels, necessitating the use of additional markers such as total iron binding capacity, serum transferrin saturation, and non-transferrin-bound iron .
Thalassemia Anemia Bone Chelation Therapy Deferoxamine Endocrine Erythropoiesis Erythropoietin Gene Gene Expression Genes Genetic Genetic Disorder Genetics Heart Hemochromatosis Hemoglobin Hypoxia Interleukin Kinase Liver Membrane Phosphorylation Protein Receptor Research RNA Serine Transcription
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