Study explores early indicators of long COVID medrxivpreprint UCSF Stanford UCLA longCOVID COVID19 coronavirus covid symptoms
By Neha MathurJul 20 2023 In a recent study posted to the medRxiv* server, researchers investigated early biomarkers of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection in a household-based cohort of individuals intensively sampled during the acute phase of coronavirus disease 2019 .
Some recent studies have found an association between PASC and prolonged viral clearance plus distinct early immune signatures. A study identified subgenomic RNA in tissue sites at autopsy for up to six months post-COVID-19. A study interviewer administered clinical questionnaires to all the participants to gather key sociodemographic, medical history, quality-of-life, symptomatology, and vaccination data. Symptom items covered 32 pre-selected symptoms.
They used quantitative RT-PCR targeting N and envelope genes of the SARS-CoV-2 genome to assess viral RNA titers in the samples and a conventional plaque assay to quantify its infectious viral titers. Likewise, they used a cytopathic effect in Vero113 hACE2-TMPRSS2 cells to measure SARS-CoV-2 infectivity.
However, only 80 of 104 participants provided blood samples for SARS-CoV-2 N-antigen and inflammatory marker testing.
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