This review explores the intricate relationship between menopause, hormonal changes, and the microbiome, emphasizing its significance in shaping women's health and well-being. It delves into the 'menopausal shift' and its effects on various microbiomes, particularly the gut, skin, and oral cavity, highlighting the potential of personalized interventions for healthy aging.
Menopause , a natural transition marking the end of menstruation, brings a cascade of physiological changes primarily driven by declining estrogen levels. This hormonal shift profoundly impacts the human body, influencing not just reproductive health but also overall well-being. Researchers have increasingly recognized the interconnectedness of hormones and the microbiome, a vast community of microorganisms residing in various parts of the body.
A recent review article published in the journal npj Women’s Health delves into the 'menopausal shift' and its effects on the microbiome, emphasizing the importance of personalized interventions for healthy aging in women. The review highlights the bidirectional relationship between hormones and the microbiome, particularly focusing on the gut, skin, and oral cavity. The article introduces the concept of the 'estrobolome,' a collection of gut microorganisms capable of metabolizing estrogen, directly influencing estrogen levels and related physiological processes during menopause. Declining estrogen levels can disrupt the balance of these microorganisms, leading to dysbiosis, a state of microbial imbalance, with implications for various health aspects. Beyond the gut, menopause also affects the skin microbiome, contributing to dryness, inflammation, and increased susceptibility to infections. The oral microbiome is also impacted, with changes in bacterial composition and an increased risk of dental issues like caries and periodontal disease. The review suggests that addressing these microbial changes through personalized dietary interventions and other targeted therapies could play a crucial role in mitigating the symptoms of menopause and promoting healthy aging in women
Menopause Microbiome Hormonal Changes Women's Health Healthy Aging Personalized Interventions
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