Understanding variations in SARS-CoV-2 evolution and clearance by immunodeficiency status medrxivpreprint COVID COVID19 SARSCov2 evolution immunodeficiency covidevolution
By Pooja Toshniwal PahariaAug 7 2023Reviewed by Benedette Cuffari, M.Sc. Immunosuppressed individuals have lower responses to severe acute respiratory syndrome coronavirus 2 vaccination and poorer coronavirus disease 2019 -related consequences. Resistance to existing treatments, including targeted antibody therapy, is a concern posed by novel SARS-CoV-2 variants of concern .
*Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information. SARS-CoV-2 spike gene-specific next-generation sequencing was used to quantify the number of unique intra-host single-nucleotide variants in the S gene present at more than 3% frequency within every sample.
The study groups had a comparable median duration from the onset of symptoms or initial SARS-CoV-2-positive report to enrollment at five and four days, respectively. Related StoriesOne month following the onset of COVID-19 symptoms or initial SARS-CoV-2-positive result, 6.5%, 15%, and 50% of NS, S-A, and S-HT individuals, respectively, showed SARS-CoV-2 presence as compared to none of the non-immunosuppressed individuals. Nucleotide and amino acid average pairwise distances were significantly greater in the S-A and S-HT groups than in the non-severe and immunocompetent groups.
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