Anticoagulant treatments are crucial for managing many conditions, such as heart disease, stroke and venous thrombosis.
Apr 30 2024University of Geneva Current options, however, carry an inherent risk of serious bleeding due to trauma or unforeseen events. A team from the University of Geneva and the University of Sydney has developed a new anticoagulant, designed to have an on-demand reversible activity, with a fast-acting ''antidote''. This approach could revolutionize the use of anticoagulants in surgery or other applications.
The group led by Nicolas Winssinger, professor in the Department of organic chemistry at the UNIGE Faculty of Science, in collaboration with Richard Payne, professor at the University of Sydney, has recently developed a new anticoagulant active ingredient with an ''antidote'' to reverse its effect rapidly and specifically.
A revolution for surgery This new anticoagulant could offer a more reliable and easier-to-use option for surgical procedures. Heparin, commonly used in this field, is a mixture of polymers of different lengths extracted from pig intestine. The result is a highly variable action, requiring coagulation tests during surgery. The new synthetic anticoagulant developed by UNIGE could help solve the problems of purity and availability associated with heparin.
Bleeding Antidote Biotechnology Blood Heart Heart Disease Heparin Hybridization Immunotherapy Oligonucleotides Research Stroke Surgery Thrombosis Trauma
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