Unique plant extract mixture has potent anti-acne effects FRO AcneVulgaris Pathogenesis Antimicrobial Phenolics SebumHypersecretion FunctionalCosmetics AcneTreatments MDPIpharma
By Hugo Francisco de SouzaJul 9 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in Pharmaceutics, researchers determined the antimicrobial efficacy of a plant-derived formula called FRO against acne pathogenesis.
Increased sebum production is considered the first step in acne, as sebum-saturated hair follicles host numerous microorganisms like CA. CA is a natural skin commensal; however, the increased proliferation of its phylotype IA1 causes inflammation and follicular pigmentation, which is externally observable as pimples.
About the study FRO is a plant-derived formula comprising a 1:1 ratio of fermentation of RV and Orostachys japonicus extracts. The formula’s efficacy was tested through in vitro analysis and antimicrobial characterization. The efficacy of FRO on CA-inducted sebum production and DHT-associated androgen hormone spikes were evaluated using oil-red-staining and Western blot analysis, respectively. Subsequently, 2′,7′-dichlorofluorescein diacetate probes were used to test the ability of FRO to neutralize the effects of reactive oxygen species , which are responsible for acne-associated hyperpigmentation and post-condition scarring.
FRO significantly reduced cell inflammation caused by CA-induced ROS and cytokine release. The long-term reduction of ROS production would likely reduce hyperpigmentation and scarring.
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