The Eunice Kennedy Shriver National Institute of Child Health and Human Development awarded $3.1 million to the University of Arkansas to study a spectrum of pediatric mitochondrial disorders caused by mutations in the mitochondria.
Reviewed by Megan Craig, M.Sc.Sep 20 2023 These disorders often impact different organs requiring energy and can lead to mitochondria-induced multiple organ disorder syndromes, or MIMODS.
Mitochondria, the tiny organelles inside cells, play a critical role in producing metabolic energy by oxidizing carbohydrates, protein and fats. In the presence of oxygen, this organelle combines with glucose and fats to create ATP, or adenosine triphosphate, which is the energy fuel for sustaining life. Many devastating diseases can arise from damage to mitochondria and could contribute to MIMODS in children and adults alike.
Starting with skin cells from children with mitochondrial disorders, our team is involved in recreating cells in vital organs impacted by the disease to capture many aspects of disease progression, which could lead to better understanding of mitochondria mutations and multiple organ failure. It is our hope that results from these studies will provide new therapies for patients impacted by mitochondrial disorders.
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