The University of Florida is leading a groundbreaking study to develop a therapy that could potentially reverse placental failure, a condition that significantly contributes to stillbirths and premature deliveries globally. This therapy, which has shown remarkable success in animal studies, aims to address a critical issue in pregnancy health.
University of FloridaDec 5 2024 The life of billions of people inhabiting Earth is owed to a temporary organ that supported and nourished them in a mother's womb.
Now, the first therapy to potentially reverse a condition that is a significant cause of stillbirth and premature delivery around the globe is being developed by a team led by a University of Florida Health researcher who has spent 20 years studying this remarkable organ. The therapy has proved highly successful in animal studies.
"This is a very exciting therapy," Jones said. "We're very happy with our results so far. If this goes well, it could be a game-changer for mothers worldwide. It has the potential to prevent so many premature births and give families hope that placental failure is not the early end of a pregnancy." The nanoparticle carries cargo -; a DNA plasmid. This is a piece of harmless DNA that, introduced into a specific type of cell in the placenta, triggers the manufacture of a protein that interacts with the cell to activate chemical processes that can change or enhance cellular function.
This hormone stimulates cell growth and development, spurs tissue repair, and ensures the fetus receives nutrition. Without it, the fetus does not receive enough nutrients to develop and grow properly. Jones is senior author of a study published in Nature Gene Therapy on Dec. 4 that she said details exciting results. It shows that in guinea pigs, the therapy boosted placental function and delivery of normal-weight offspring. Guinea pigs have biological and physiological conditions during pregnancy that parallel humans.
Placental Failure Premature Delivery Stillbirth University Of Florida Pregnancy Health Research
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