An estimated 76,000 Oklahomans are living with Alzheimer's disease, a number that has surged by 13% in just five years. Yet, despite the increasing need for effective treatments, therapies for age-related dementia have largely failed to slow or halt the disease's progression.
University of OklahomaJan 29 2025 An estimated 76,000 Oklahomans are living with Alzheimer's disease, a number that has surged by 13% in just five years. Yet, despite the increasing need for effective treatments, therapies for age-related dementia have largely failed to slow or halt the disease's progression.
Sreemathi Logan, Ph.D., Assistant Professor, Department of Biochemistry and Physiology, OU College of Medicine Logan and colleagues at the Oklahoma Center for Geroscience and Healthy Brain Aging developed a nocturnal testing model to assess an animal's ability to relearn a simple task. Logan and members of her lab are working to address this research question in collaboration with the Geroscience Center of Biomedical Research Excellence and the Oklahoma Nathan Shock Center, both on the OU Health Sciences campus, and the Oklahoma Medical Research Foundation.
"We're looking at over-expression of target proteins that can benefit astrocyte metabolism and see if that improves cognition," Logan said. "That's one avenue we're trying to take to see how we can intervene within cells to improve cognition as we get older."
Aging Alzheimer's Disease Antibodies Astrocyte Biochemistry Brain Medicine Metabolism Neurons Ph Physiology Protein Research
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