Organosulfur skeletons are crucial in many fields, including pharmaceuticals and electronics. Synthesizing organosulfur skeletons requires o-bromobenzenethiols. However, conventional methods face challenges due to quick oxidation and formation of highly reactive intermediates.
Unlocking complex sulfur molecules: Novel approach for synthesis of functionalized benzenethiol equivalents Researchers have now developed a new method for synthesizing o-bromobenzenethiols from aryne intermediates via bromothiolation. This method can pave the way for the synthesis of new organosulfur compounds with applications in diverse fields.
The researchers utilized potassium xanthate instead of hydrogen sulfide, owing to its better reactivity in aryne reactions and pentafluorophenyl bromide as an electrophilic brominating reagent. This combination allowed them to efficiently produce complex o-bromobenzenethiol equivalents called aryl xanthates. Notably, this method demonstrated good tolerance for various chemical groups and prevented the formation of unwanted products.
This study opens new possibilities for the synthesis of organosulfur compounds with diverse applications in many fields."Further studies on expansion of scope and applications of this method for synthesis of bioactive organosulfur compounds are underway in our laboratory," concludes a hopeful Prof. Yoshida.Tokyo University of Science."Unlocking complex sulfur molecules: Novel approach for synthesis of functionalized benzenethiol equivalents." ScienceDaily.
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