Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells (HSCs) are remarkably long-lived.
Apr 30 2024Baylor College of Medicine Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells are remarkably long-lived. HSCs are blood-forming cells – they give rise to rapidly dividing progenitor cells , which in turn generate hundreds of billions of cells to fulfill the daily demand of oxygen-delivering red blood cells , disease-fighting white blood cells and clot-forming platelets.
Dr. André Catic, corresponding author, assistant professor and CPRIT Scholar in Cancer Research in the Huffington Center on Aging at Baylor Molecular chaperones at work Previous studies have shown that mammalian cells express several hundreds of molecular chaperones, proteins that preserve or change the three-dimensional conformation of existing proteins. Cyclophilins, one of the most abundant chaperones, have been implicated in the aging process. However, how they affect cellular proteins has not previously been studied.
Related StoriesIntrinsically disordered proteins naturally change their 3-D conformation to interact with different proteins, nucleic acids or other molecules. Consequently, proteins rich in intrinsically disordered regions regulate many cellular processes by promoting specific activities between molecules. "Due to their flexible nature, intrinsically disordered proteins are inherently prone to aggregation.
Aging Blood Bone Bone Marrow Cancer Cell Cell Biology Chaperones Enzyme Medicine Oxygen Platelets Progenitor Cells Protein Red Blood Cells Research Stress
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