Less than a decade ago, when Dr. Hansruedi Mathys launched an ambitious project to create an annotated library of all the gene readouts stored within 100 individual brain cells, the task felt daunting.
University of PittsburghJul 25 2024
Mathys, who pioneered single-cell transcriptomic analysis on post-mortem human brain tissue during his postdoctoral training and is now an assistant professor of neurobiology at the University of Pittsburgh School of Medicine, says that the resulting atlas of the aging human brain holds molecular insights into the brain's vulnerability and resilience.
Our recent findings have made me more hopeful than ever that it might be possible to artificially induce such resilience in people who otherwise are susceptible to memory loss." In the study, published this week in Nature, Mathys and his colleagues at the Massachusetts Institute of Technology analyzed transcriptomes of cells across six distinct brain regions that are often affected by Alzheimer's pathology.
Brain Alzheimer's Disease Cell Cortex Gene Pathology Ph
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