Unravelling the factors influencing host tropism of SARS-CoV-2-related bat coronaviruses biorxivpreprint tropism zoonosis covid SARSCoV2 bats COVID19 coronavirus host research
By Neha MathurApr 18 2023Reviewed by Lily Ramsey, LLM In a recent study posted to the bioRxiv* preprint server, researchers investigated host angiotensin-converting enzyme 2 tropism of severe acute respiratory syndrome coronavirus 2 -related coronaviruses infecting Rhinolophus bats.
Interactions between viral proteins and host receptors determine the host range of a virus. For instance, human influenza A viruses preferentially bind α2-3-linked sialic acid; conversely, avian IAVs bind α2-6-linked sialic acid. They also synthesized the human immunodeficiency virus type 1 -based pseudoviruses having the spike glycoproteins of SC2r-CoVs, BANAL-20-236, and BANAL-20-52.
Study findings The study findings pointed at differential ACE2 tropism in SC2r-CoVs infecting Laotian bat species, B236 and B52.
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