This study explores urinary pentosidine as a potential biomarker for muscle strength and physical performance in young men, revealing significant inverse correlations with key musculoskeletal parameters. Findings suggest its potential role in assessing glycation stress and guiding health interventions.
By Tarun Sai LomteReviewed by Susha Cheriyedath, M.Sc.Nov 24 2024 Discover how a simple urinary biomarker is unlocking new insights into muscle strength, bone health , and physical fitness in young adults, paving the way for better health monitoring and interventions.
Peak bone and muscle mass during early adulthood is essential to sustain bone and muscle mass losses in late adulthood. Pentosidine is representative of the crosslinked structure of advanced glycation end products that form after the oxidation of bone collagen crosslinks. Urine pentosidine levels are known to increase with age and have been associated with various health parameters in older adults.
The thickness of the anterior thigh and rectus femoris muscles of the dominant leg was measured using an ultrasound system. Further, the heel stiffness index was measured by quantitative ultrasound. The team conducted four performance tests: grip strength, a timed up and go test, a functional reach test, and a 30-second chair stand test.
Subjects were asked to avoid drinking and eating from two hours before the experiment. High-performance liquid chromatography was performed to measure urinary pentosidine levels. Further, N-telopeptide of type 1 collagen and cortisol levels in urine were measured using a chemiluminescent enzyme assay. Correlations between urinary biomarkers and other variables were calculated using Pearson’s correlation analysis.
Conclusions In sum, the findings illustrate inverse associations of urinary pentosidine levels with grip strength and the thickness of the dominant leg's rectus femoris and anterior thigh muscles. Further, urinary pentosidine levels showed a marginal inverse correlation with the FR test and no associations with other physical performance parameters, such as the TUG and 30-s chair stand tests.
Biomarker Bone Bone Health Collagen Glycation Musculoskeletal Ultrasound
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