Researchers in the US analyzed swine-origin influenza viruses, identifying key mutations that could reduce antiviral drug effectiveness and threaten pandemic preparedness.
By Dr. Sushama R. Chaphalkar, PhD.Reviewed by Susha Cheriyedath, M.Sc.Oct 9 2024 Swine-origin influenza viruses show mutations that resist antiviral drugs, posing a pandemic risk and highlighting the urgent need for ongoing surveillance and updated treatment strategies.
Background Swine-origin influenza viruses are enzootic in pig populations worldwide, making pigs a key "mixing vessel" where human, bird, and pig influenza viruses can combine, increasing pandemic risks. Variant swine-origin viruses are monitored under the World Health Organization’s International Health Regulations due to their potential for generating new pandemic strains. Influenza antiviral drugs face challenges from genetic mutations, reassortments, and antiviral resistance, especially for matrix-2 blockers.
Control experiments utilized CDC antiviral susceptibility reference virus panels. For genetic analysis, whole-genome sequences were generated and analyzed.
Pandemic Antibodies Antibody Assay Drugs Efficacy Evolution Genetic Genome H1N1 H1N2 H3N2 Infectious Diseases Laboratory Oseltamivir Protein Public Health Vaccine Virus
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