The National Institutes of Health has provided $3.5 million for a large-scale clinical trial testing a radical new approach to managing type 2 diabetes that, in an earlier study, put almost 70% of participants in remission without weight loss or medication.
The approach was developed by UVA Health’s Daniel J. Cox, PhD. It is built on the notion that educating people about how to make wise dietary and exercise choices can allow them to control their blood sugar and possibly even alter the course of the disease.
Targeting Type 2 Diabetes More than 30 million people around the world have type 2 diabetes, a condition in which the body becomes unable to regulate blood sugar. This can lead to heart disease, kidney disease, blindness and a host of other serious medical conditions. Type 2 diabetes typically affects people over age 45 but is increasingly striking children, teenagers and young adults. Many people must use medication or insulin injections to manage the condition.
The approach showed promise in a small initial trial. Seventeen adults recently diagnosed with type 2 diabetes tested the GEM program in combination with continuous glucose monitoring. They also received text messages to help them stay on track. After 3 months, 67% were in remission, and only one participant needed to begin medication.
Related StoriesCox’s latest study will build on the prior research to determine, at a larger and longer scale, if GEM offers a safe and effective new tool for managing type 2 diabetes among the recently diagnosed. The randomized clinical trial will enroll 200 people in Virginia and Colorado and assess, over five years, whether GEM helps them better control their blood sugar and reduces their need for medication.
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