Vaccine efficacy and booster dose combinations among 18.9 million adults in the early phase of Omicron Efficacy Omicron Vaccine Coronavirus Disease COVID CIDJournal CDCgov
By Suchandrima BhowmikFeb 12 2023Reviewed by Danielle Ellis, B.Sc. It has been demonstrated that the COVID-19 vaccine protects against severe illness, hospitalizations, and death when infected with SARS-CoV-2, including the Omicron variant. Previous studies have compared homologous vaccine schedules that used the same vaccine products and heterologous vaccine schedules that used different vaccine products.
About the study The study involved two patient-level datasets: pharmacy and medical claims data, licensed from HealthVerity, Inc., a healthcare data technology company specializing in COVID-19 vaccine administration data received from the Federal Retail Pharmacy Program and privacy-preserving record linkage . Real-world data licensed from HealthVerity, Inc.
Individuals were excluded from the study if they were below 18 years of age at administration of the first vaccine, of unknown age or sex, were immunocompromised, and if they received a booster before September 23, 2021, and after March 15, 2022, or if they received Ad26.COV2.S booster followed two mRNA primary doses. The identification of outcomes took place through the International Classification of Diseases, Tenth Revision, Clinical Modification code of U07.1.
The incidence of all outcomes was the highest in participants who received two Ad26.COV2.S doses. However, participants who received an mRNA booster were observed to show higher vaccine effectiveness against all outcomes, while the effectiveness was not significantly different for three mRNA and Ad26.COV2.S+mRNA. Ad26.COV2.S + mRNA doses and three mRNA doses were observed to show higher rVE against the three mildest outcomes compared to two Ad26.COV2.
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