Vaccine MVA-BN shows consistent, robust immunogenicity and safety results Efficacy Smallpox Vaccine MVABN Mpox uabmedicine BavarianNordic
By Nidhi Saha, BDSDec 5 2022Reviewed by Benedette Cuffari, M.Sc. A recent article published in the journal Vaccine describes the results of a phase III clinical trial that showed consistent immunogenicity for a freeze-dried formulation of Bavarian Nordic's Modified Vaccinia Ankara .
Drug Discovery eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy The strategic use and stockpiling of orthopoxvirus vaccines are of great importance to public health, as vaccination remains the only effective protection against orthopoxvirus-induced diseases, such as smallpox and mpox.
To enhance the long-term storage and distribution of smallpox vaccine stockpiles, an FD formulation of the MVA-BN vaccine was developed. In contrast to the licensed liquid-frozen formulation of the MVA-BN smallpox vaccine, the FD formulation offers greater storage flexibility and shelf life. To determine the vaccine's consistency, total and neutralizing antibody titers, seroconversion rates, the ratio or consistency of geometric mean titers between group lot pairings, and correlation analysis between total and neutralizing antibody titers were used.
MVA-BN was found to produce maximal humoral responses two weeks following the second vaccine dose. The present trial consistently showed peak antibody titers in the 3 log10 range that protected against infection. The most frequently reported adverse effects following FD MVA-BN treatment were local and general reactions of mild-to-moderate intensity that were self-limiting in nature. These incidents' frequency, intensity, and duration were also evenly distributed among the three lots. In addition, adverse effects did not appear to be clustered across all lot groups.
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