Many clinicians delay CD20 treatment until vaccine schedules are complete. A study suggests that this precaution may not be necessary.
The study, the first to examine vaccine safety and immunogenicity in highly active MS, revealed high seroprotection rates following receipt of vaccines for COVID-19 andOn the basis of these findings, investigators created an algorithm that clinicians can use to map an immunization schedule in patients who might otherwise delay initiation of disease-modifying therapy until they are fully vaccinated.
Reports of disease worsening following vaccination"have raised controversy around vaccine safety," the authors write. The issue is especially relevant to those with highly active MS due to the scarcity of available data in this population. They also compared John Cunningham virus serostatus between the two periods, as well as immunoglobulin G titers for each vaccine.
Participants who initiated or continued treatment with natalizumab completed their vaccination regimen without any incidents of progressive multifocal leukoencephalopathy or disease activity rebound following natalizumab discontinuation.
Multiple Sclerosis MS MS - Multiple Sclerosis Immunizations Vaccination COVID-19 Vaccine Coronavirus Vaccine Vaccine Vaccines Hepatitis B HBV - Hepatitis B Virus HBV Children Child Childhood Pediatrics Kids COVID-19 2019 Novel Coronavirus 2019-Ncov Wuhan Coronavirus Human Coronavirus HKU1 Human Coronavirus OC43 Hcov-OC43 Human Coronavirus 229E Hcov-229E
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