The largest ever clinical trial of T cell therapy for solid tumors has ended, heralding a new era for precision T cell therapy.
SingHealthNov 11 2024 Led by a Singapore clinician-scientist, the multinational, phase III VANCE trial demonstrates that Singapore has the expertise and capabilities to run a large-scale global cell therapy trial. Results were published in the high impact factor journal, Annals on Oncology , in October 2024.
"This international T cell therapy trial driven by Singapore's biotech and the National Cancer Centre Singapore represents a significant milestone. The delivery of high-quality T cells at large scale has been a major barrier for extending the applications of these therapies.
There have been efforts to find more effective treatments for advanced NPC. NPC is closely associated with the Epstein-Barr virus , making NPC a good candidate to treat with immunotherapy targeting EBV. Small studies have shown that EBV-specific cytotoxic T cell therapy, a type of T cell therapy, produces clinical responses and clinical benefit in NPC patients.
Related StoriesA total of 330 patients were enrolled between July 2014 and January 2020 at 23 trial sites in Singapore, Malaysia, Thailand, Taiwan and the United States. Participants were randomly divided into two groups – one that received chemotherapy followed by EBV-CTL therapy, and one that received chemotherapy alone.
Clinical Trial Immunotherapy Biomarker Blood Cancer Carboplatin Carcinoma Chemotherapy Epstein-Barr Virus Gemcitabine Hospital Immune System Laboratory Manufacturing Medicine Nasopharyngeal Oncology Proton Therapy Research Virus
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