Malabsorption disrupts vitamin absorption, leading to deficiencies in essential nutrients like A, D, E, K, C, and B12, with significant health implications.
By Dr. Sanchari Sinha Dutta, Ph.D.Reviewed by Danielle Ellis, B.Sc. Why does vitamin absorption matter?Vitamin E malabsorptionFurther reading
Vitamin deficiency can occur due to low intake of vitamin-containing foods or intestinal malabsorption of vitamins from foods. Chronic malabsorption of these micronutrients can cause a range of health complications, including skin disease, dry eyes and vision impairment, bone disorders, hair loss, anemia, immune deficiency, and neurological problems 2.
Vitamin A malabsorption Fat-soluble vitamin A plays a major role in regulating the visual cycle, immune function, and cell differentiation. Impaired fat absorption after intestinal resection and intestinal bypass can lead to vitamin A malabsorption 4. Vitamin D deficiency can lead to muscle weakness, spasms, pain, and aggravation or recurrence of gastrointestinal tract diseases, especially inflammatory bowel disease 6.
Can Magnesium Supplements Help You Sleep Better? Vitamin K deficiency can also occur after warfarin therapy or anticoagulant rodenticide toxicity, as these compounds inhibit the enzyme vitamin K epoxide reductase, which is required for vitamin K recycling 8.
Pernicious anemia is characterized by autoantibody-mediated destruction of stomach cells, leading to reduced secretion of acids and enzymes required for releasing food-bound vitamin B12. Autoantibodies generated against intrinsic factors prevent vitamin B12 from binding to them. These factors collectively lead to a substantial reduction in vitamin B12 absorption 11.
References 1. Vitamins: MedlinePlus Medical Encyclopedia. Accessed November 27, 2024. https://medlineplus.gov/ency/article/002399.htm 5. Vitamin D Deficiency. Yale Medicine. Accessed November 28, 2024. https://www.yalemedicine.org/conditions/vitamin-d-deficiency
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