A new approach for delivering miniature research tools into the interior of egg cells and embryos has been developed at the Marine Biological Laboratory (MBL), resolving a major bottleneck to using the gene-editing tool CRISPR-Cas9 in many research organisms.
Marine Biological Laboratory Sep 11 2024 A new approach for delivering miniature research tools into the interior of egg cells and embryos has been developed at the Marine Biological Laboratory , resolving a major bottleneck to using the gene-editing tool CRISPR - Cas9 in many research organisms. A paper detailing the new approach, called VitelloTag, has been accepted by the journal Development.
The new delivery approach was inspired by a yolk protein found in most animals, called vitellogenin, which provides a source of energy to the growing egg. Related StoriesThe team has used VitelloTag successfully in two distantly related species that are important for developmental biology: the sea star and the acorn worm . And since their paper went online, "we've been getting a lot of interest from people in different institutions, who want to try it in their own particular critter," Swartz said.
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