This study found that a Western diet doubles the growth of endometriotic lesions in mice and depletes the gut microbiome's beneficial bacterium, Akkermansia muciniphila, which may exacerbate endometriosis symptoms.
By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Nov 12 2024 Accelerated lesion growth and key gut bacteria loss link the Western diet to heightened endometriosis risk, opening new discussions on diet as a potential intervention.
Despite being a benign condition, endometriosis causes significant morbidity in affected women, 10% of whom are of reproductive age. Endometriosis is characterized by the abnormal growth of tissues resembling that of the uterine lining or endometrium outside of the uterine cavity. At seven weeks, mice were sacrificed. Both the characteristics of the lesions and the composition of the gut microbiome were analyzed.
Metabolic differences with WD Serum glucose levels were reduced in mice with endometriosis as compared to the original endometriosis-free mice before they became recipients of uterine tissue implants, perhaps reflecting higher glucose consumption.
Diet Anti-Inflammatory Dysbiosis Endometriosis Endometrium Glucose Immunity Inflammation Macrophage Medicine Metabolism Microbiome Pain Probiotic Syndrome
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