What genes are associated with asthma exacerbations? ULL Asthma AsthmaExacerbation Genes
By Tarun Sai LomteNov 29 2022Reviewed by Aimee Molineux In a recent study published in the Journal of Investigational Allergology and Clinical Immunology, researchers reviewed the genomics, transcriptomics, and epigenetics of asthma exacerbations .
It is critical to identify relevant biomarkers/predictors of AEs to guide the prevention/reduction of AEs. Evidence suggests ethnic differences in AE patterns across the world. Puerto Ricans and African Americans in the US show higher rates of AEs, whereas Southern European countries have higher rates of AEs.
Studies have identified associations between numerous 17q12-21 variants and the expression of nearby genes in bronchial epithelial cells. Many variants are also located within binding sites for interferon regulatory factors, suggestive of effects through antiviral pathways. One GWAS revealed an association between the asthma-related human leucocyte antigen DQ Beta 1 and AEs in Hispanic/Latino children and British adults.
Several studies reported that genomic regions harboring the loci associated with AEs in children taking ICS are implicated in bronchodilator responsiveness, baseline lung function, and responses to viral infections. Likewise, admixture mapping studies have uncovered genetic variants associated with bronchodilator response, lung function, asthma, and immunoglobulin E levels.
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