What is the effect of prior BCG vaccination on the immunogenicity and efficacy of subsequent COVID-19 vaccination? biorxivpreprint mcgillu UofT universitelaval vaccine vaccination COVID19 coronavirus covid
By Bhavana KunkalikarMar 28 2023Reviewed by Danielle Ellis, B.Sc. *Important notice: bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Nevertheless, while certain COVID-19 vaccines are in their phase I/II clinical trials, the effectiveness of this strategy has proven elusive to date. However, the consequences of earlier vaccines and infections are yet to be considered in these models. The effectiveness of a prime-boost immunization schedule with BCG was also studied. Female C57BL/6 mice were inoculated intraperitoneally with 106 colony-forming units of the BCG strain harboring an empty plasmid ) one month before i.n. immunization with Ad. In place of BCG and Ad, PBS was administered to the naive controls.
Results Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Two months following vaccination, Ad-immunized mice demonstrated a substantial reduction in generating infectious SARS-CoV-2 in oral samples. However, when challenged with SARS-CoV-2 six months after vaccination, virus titers noted in vaccinated subjects were similar to those in unvaccinated mice.
The team also discovered that by six months after vaccination, while one Ad dose was effective in lowering viral burden in comparison to controls, this decrease did not have statistical significance. While Ad retained some protective impact after six months, one BCG dose before Ad vaccination enhanced its capacity to monitor viral replication in the respiratory tract.
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