It’s been twenty years since the Human Genome Project was completed. Our “Babbage” podcast investigates how far the field has come and the challenges that remain in applying genomics to clinical practice
’s health editor and Geoff Carr, our senior editor for science and technology, reflect on the completion of the Human Genome Project in the early 2000s and the gaps that still remain. Natasha also visits the, to explore the next frontiers for genomics in medicine.
She meets the outgoing director, Mike Stratton, the incoming director, Matt Hurles and the boss of the European Bioinformatics Institute, Ewan Birney. Plus, Mathew Davies, an engineer at the Sanger Institute, and his team, discuss the challenges with storing and processing vast amounts of sequencing data. Alok Jha,To dive deeper on genomics, find our recent episode from the
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Modelling human behaviour in cognitive tasks with latent dynamical systems - Nature Human BehaviourThe authors introduce a deep learning framework to reproduce sequences of response times and use it to provide evidence for a stability–flexibility trade-off underlying task-switching costs.
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PhyloMed: a phylogeny-based test of mediation effect in microbiome - Genome BiologyMicrobiome data from sequencing experiments contain the relative abundance of a large number of microbial taxa with their evolutionary relationships represented by a phylogenetic tree. The compositional and high-dimensional nature of the microbiome mediator challenges the validity of standard mediation analyses. We propose a phylogeny-based mediation analysis method called PhyloMed to address this challenge. Unlike existing methods that directly identify individual mediating taxa, PhyloMed discovers mediation signals by analyzing subcompositions defined on the phylogenic tree. PhyloMed produces well-calibrated mediation test p-values and yields substantially higher discovery power than existing methods.
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Study indicates that the planetary health diet increases probiotic-associated bacteria in the gut microbiomeStudy indicates that the planetary health diet increases probiotic-associated bacteria in the gut microbiome Nutrients_MDPI LstSaar diet planetaryhealthdiet health nutrition microbiome microbiota bacteria gutmicrobiome guthealth
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Bedside 'human milk calorie guide' enhances nutrient fortification for preterm infantsThis paper describes the development and validation of a bedside color-based tool called the ‘human milk calorie guide’(HMCG) for differentiating low-calorie human milk using commercial human milk analyzers as the gold standard.
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Cricket ground 'absolutely ruined' by human waste and tyre marksA group of travellers, reported to be towing 18 caravans, moved onto the grounds of Cavaliers & Carrington Cricket Club on Esher Grove, Mapperley Park, at around 9pm on Sunday, April 16.
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