What was the prevalence of germline genetic testing among patients diagnosed with cancer in California and Georgia between 2013 and 2019? JAMA_current Stanford EmoryUniversity USC genetics genetictesting cancer
By Neha MathurJun 8 2023Reviewed by Danielle Ellis, B.Sc. In a recent article published in the JAMA Network, researchers performed an observational study to determine the prevalence of germline genetic testing among all patients aged 20 years or older diagnosed with cancer between January 1, 2013, and March 31, 2019, in two United States , California and Georgia.
Guidelines strongly recommend germline testing for cancer patients with gynecological cancers, e.g., breast and ovarian cancers. It is also recommended for other cancers, like pancreatic, rectal, and prostate cancers. With recent advancements in DNA sequencing technology, testing for several types of genes has become feasible, and its financial cost has also decreased. However, studies have barely explored the benefits of germline genetic testing in patients diagnosed with cancer.
Results In the two-year study duration, 93052 of 1369602 patients diagnosed with cancer underwent genetic testing, i.e., only 6.8%. Genetic testing rates surged over time but remained far below 100% in 2021 for most cancer types. In addition, the racial and ethnic inequities in germline genetic testing persisted throughout 2021 in Asian, Black, and Hispanic patients but not in non-Hispanic White patients.
Further, the authors noted that germline genetic testing rates did not vary by cancer stage, which, in turn, reflected inadequate testing of patients with advanced-stage cancers and not offering testing to their relatives at high-risk. Studies have shown the benefits of poly polymerase inhibitors in multiple cancer types. Thus, testing rates increased over time, especially for patients with pancreatic cancer, from 1.2% to 18.6% between 2013 and 2019.
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